Peb cov noob, thiab lwm yam, los txiav txim seb cov tshuaj caffeine rau peb li cas
Caffeine rhiab heev hais txog qhov ntau npaum li cas rau caffeine muaj nyob hauv peb lub cev. Cov neeg uas tsis muaj caffeine rhiab heev tuaj yeem muaj cov tsos mob tseem ceeb - xws li kev ntxhov siab, tshee, mob taub hau, mob siab, thiab insomnia - tom qab noj me me cov caffeine uas muaj me me, Cov neeg uas muaj caffeine yuav tsum ua kom tsis txhob muaj caffeine zoo rau nws.
Yuav ua li cas rhiab ib tug neeg yog caffeine yog txiav txim los ntawm ntau yam tseem ceeb xws li lub hnub nyoog thiab kev sib deev, tab sis qhov loj tshaj yog qhov tseem ceeb. Hauv cov poj niam, caffeine rhiab heev kuj tau zoo los ntawm kev siv cov tshuaj tiv thaiv, thiab cev xeeb tub.
Yuav ua li cas Caffeine metabolized
Caffeine sai tau los ntawm cov hnyuv rau hauv cov hlab ntsha, thiab nws nkag mus rau hauv cov ntshav ntawm lub hlwb tawm hauv lub hlwb. Nws tseem tuaj yeem hla lub tsho hauv cov poj niam cev xeeb tub.
Hauv lub hlwb, caffeine khi rau adenosine receptors, yog li tiv thaiv adenosine los ntawm attaching rau lawv. Vim hais tias adenosine xa lub hlwb lus hais tias nws yog lub sij hawm mus pw, thaiv cov adenosine receptors muaj cov nyhuv ntawm qhov ua rau muaj kev vam meej.
Caffeine metabolised hauv lub siab los ntawm ib qho enzyme hu ua CYP1A2 rau theophylline, paraxanthine thiab theobromine, thiab tom qab ntawd tawm los ntawm ob lub raum mus rau hauv cov zis. Ib nrab ntawm lub neej ntawm caffeine feem ntau yog 4 - 6 teev, uas yog qhov caffeine ntev npaum li cas rau peb.
Dab tsi cuam tshuam txog Caffeine Sensitivity?
Kev mob tshwm sim rau caffeine yog txiav txim siab los ntawm kev ua ntawm CYP1A2 enzyme hauv daim siab. Qhov ntau dhau ntawm CYP1A2, qhov tsawg dua peb tseem caffeine. Muaj ob peb yam cuam tshuam rau kev ua CYP1A2:
- hnub nyoog: CYP1A2 kev ua si nyhav rau lub hnub nyoog, yog li cov neeg laus yuav mob siab rau caffeine
- poj niam txiv neej: Cov poj niam yuav muaj tsawg dua CYP1A2 kev ua si li txiv neej.
- Kev siv qhov ncauj tsis haum xeeb thiab cev xeeb tub: estrogens inhibit CYP1A2 kev ua si, thiab caffeine rhiab nce
- Genetic pleev: Muaj ntau hom gene variants tau tam sim no tau txheeb xyuas tias cuam tshuam rau CYP1A2 kev ua si.
Peb Cov Noob Hlob thiab Caffeine
Genetic testing tau qhia peb cov ntsiab lus ntawm caffeine rhiab heev rau peb cov caj pleev:
- Kev Cog Tseg rau Caffeine : Cov neeg no muaj kev ua haujlwm CYP1A2 tsawg heev. Lawv yuav muaj ib qho lus teb rau cov me me uas muaj caffeine tsawg, thiab feem ntau yuav ua rau cov neeg yos hav zoov thiab cov neeg tuag taus.
- Mob Tawv Zog Kom Caffeine : Qhov no yog qhov feem coob ntawm cov neeg. Lawv muaj peev xwm haus tau txog li 400 mg ntawm caffeine ib hnub twg tsis muaj kev phom sij.
- Tsis tshua raug Caffeine : Cov neeg no muaj cov kev ua haujlwm CYP1A2 zoo heev, thiab feem ntau tsis muaj kev cuam tshuam ntawm kev haus caffeine. Cov neeg haus luam yeeb feem ntau tau nce cov dej CYP1A2.
Thaum kuaj caj ces yuav categorize koj cov caffeine rhiab heev, muaj kev kuaj xyuas yog feem ntau tsis tsim nyog rau koj paub - tsawg kawg feem ntau hais lus - txawm tias koj tsis tshua muaj caffeine heev. Thiab yog tias koj yog, nws muaj peev xwm hais tias tsis muaj leej twg xav tau qhia rau koj kom txiav rov qab.
Cev xeeb tub thiab Caffeine Sensitivity
Cev xeeb tub nti tawm tau zoo ua rau caffeine. Ib nrab ntawm lub neej hauv caffeine rau cov poj niam cev xeeb tub yog feem ntau plaub zaug ntev dua rau cov poj niam uas tsis xeeb tub - feem ntau mus txog 16 xuab moos. Tsis tas li ntawd, caffeine nkag nkag rau hauv cov hlab ntshav hauv plab - thiab tus me nyuam hauv plab muaj ntau yam tsawg kawg ntawm CYP1A2. Thaum muaj teeb meem loj rau tus me nyuam hauv plab los ntawm leej niam lub cev caffeine tau tsis tau muab teev tseg, qhov teeb meem no tsis tau kawm ntau yam. Feem ntau, cov poj niam cev xeeb tub yuav tsum tsis txhob ua los yog tsis txhob muaj caffeine.
> Qhov chaw:
> Cornelis MC, Byrne EM, Esko T, li al. Lub Kas Fes thiab Caffeine Nthuav Thaj Tsam Tswv Yim. Genome-wide meta-analysis qhia txog 6 lub chaw tshiab nrog kev noj haus cwj pwm. Molecular Psychiatry 20, 647-656 (Tsib Hlis 2015) | doi: 10.1038 / mp.tos.107
> Grant DM, Tang BK, Kalow W. Qhov txawv ntawm cov caffeine metabolism hauv. Chaw Kho Mob Pharmacology & Therapeutics, 33 (5), 591-602, 1983.
> Grosso LM, Bracken MB. Caffeine metabolism, genetics, thiab perinatal cov txiaj ntsig: kev tshuaj ntsuam xyuas qhov kev soj ntsuam thaum muaj menyuam hauv plab. Ann Epidemiol 2005; 15: 460.